Assoc Prof Brian Hyland

Department of Physiology, School of Medical Science University of Otago, PO Box 913, Dunedin, New Zealand Phone +64 3 479 7342; Fax +64 3 479 7323 Email: brian.hyland@stonebow.otago.ac.nz

Membership of research focus: "Cellular & Molecular Neuroscience"

Current research focuses on:

1. Neurophysiology of motor control pathways involved in control of skilled movement.
2. Neurophysiology of midbrain dopamine systems and pathways which modulate dopamine neuron activity.
3. Effects of abnormal dopamine activity such as occurs in Parkinson's disease on activity in the motor control pathways.

Research currently funded by:

Health Research Council and New Zealand Neurological Foundation.

Current Lab personnel:

• Research Fellow: Dr Louise Parr-Brownlie (HRC)
• Post-doctoral Fellow: Dr Yuhong Li
• Assistant Research Fellows: Justine Fuller, Roseanna Smither
• PhD students: Karen Young, Chris Perk, Rebecca Scott.

Collaborations:

• Professor Jeff Wickens, Okinawa Institute of Science & Technology, Japan and Department of Anatomy & Structural Biology, Otago
• Professor Gordon Arbuthnott, Okinawa, Japan
• Associate Professor J. Greg Anson, School of Physical Education
• Dr Alessandro Villa, Lausanne Switzerland & Grenoble France
• Prof. Jason Chen, Tainan, Taiwan

Some links to collaborators and other sites of interest:

• The most scenic neuroscience conference in the world.
• Otago Basal ganglia Research group: http://anatomy.otago.ac.nz/research/basal-ganglia/

Recent Publications:

Arbuthnott, G., Dejean, C., & Hyland, B. (2009) Antidromic cortical activity as the source of therapeutic actions of deep brain stimulation? In: Cortico-subcortical dynamics in Parkinson's disease. Ed. Tseng, K.Y. Humana Press. In Press. Available on-line at http://www.springerlink.com/content/978-1-60327-251-3

Wu, Y-N., Chen, J-J.J., Zhang, L-Q., & Hyland, B.I. Regulation of hind-limb tone by adenosine A2A receptor in rats. Neuroscience, 159: 1408-1413, (2009).

Dejean, C., Hyland, B., & Arbuthnott, G. Cortical effects of subthalamic stimulation correlate with behavioral recovery from deopamine antagonist induced akinesia. Cerebral Cortex, 19: 1055-1063, (2009).

Pan, W-X., Schmidt, R., Wickens, J.R., & Hyland, B.I. Tripartite mechanism of extinction suggested by dopamine neuron activity and temporal difference model. Journal of Neuroscience, 28(39): 9619-9631, (2008).

Chen, H-Y., Wu, J-S., Hyland, B.I., Lu, X-D., Chen, J-J.J. A low noise remotely controllable wireless telemetry system for single-unit recording in rats navigating in a vertical maze. Medical and Biological Engineering and Computing, 46: 833-839, (2008).

Wu, Y.-N., Hyland, B.I., & Chen, J.-J.J. Biomechanical and electromyogram characterization of neuroleptic induced rigidity in the rat. Neuroscience, 147: 183-196 (2007).

Wickens, J.R., Budd, C.S., Hyland, B.I., & Arbuthonott, G.W. Striatal contributions to reward and decision making. Making sense of regional variations in a reiterated processing matrix. Ann NY Acad Sci, 1104: 192-212 (2007).

Wickens, J.R., Hyland, B.I., & Tripp, G. Frontostriatal mechanisms in reinforcement: Implications of ADHD. In: Recent Breakthroughs in Basal Ganglia Research. Bezard, E. (ed). New York, Nova SCience (2006) pp. 65-80.

Pan, W.X, & Hyland, B.I. Pedunculopontine tegmental nucleus controls conditioned responses of midbrain dopamine neurons in behaving rats. J Neurosci. 25: 4725-4732 (2005).

Pan, W.X., Schmidt, R., Wickens, J.R., & Hyland, B.I. Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward-learning network. J Neurosci. 25: 6235-6242 (2005).

Parr-Brownlie, L.C., & Hyland, B.I. Bradykinesia induced by dopamine D2 receptor blockade is associated with reduced motor cortex activity in the rat. J Neurosci. 25: 5700-5709 (2005).

Reynolds, J.N., Hyland, B.I., & Wickens, J.R. Modulation of an afterhyperpolarization by the substantia nigra induces pauses in the tonic firing of striatal cholinergic interneurons. J Neurosci. 24: 9870-9877 (2004).

Wickens, J.R., Reynolds, J.N., & Hyland, B.I. Neural mechanisms of reward-related motor learning. Curr Opin Neurobiol 13: 685-90 (2003).

Hyland, B.I., Reynolds, J.N.J., Hay, J., Perk, C.G., & Miller, R. Firing modes of midbrain dopamine cells in the freely moving rat. Neuroscience 114: 475-492 (2002).

Reynolds, J.N.J., Hyland B.I., & Wickens J.R. A cellular mechanism of reward-related learning, Nature, 413: 67-70 (2001).

Hajos, M., Hoffmann, W.E., Tetko, I.V., Hyland, B., Sharp, T., & Villa, A.E.P. Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT1A receptors. Neuroscience Letters 304: 129-132 (2001).

Anson, J.G., Hyland B., Kötter R., & Wickens J.R. Parameter precueing and motor preparation. Motor Control. 4: 221-231 (2000).

Hyland, B.I. Relationships of substantia nigra dopamine neurone activity to behaviour. In, Brain Dynamics and the Striatal Complex. R. Miller and J.R. Wickens (eds.) Amsterdam, Harwood Academic Publishers, (2000) pp. 1-27 [ISBN 90-5702-478-0].