8th September, 2017
PhD student wins two awards at Queenstown Research Week
Congratulations to Mauro Silva, PhD student in the Department of Physiology. Mauro is supervised by Dr Rebecca Campbell.
8th September, 2017
Triennial Medal awarded to Professor Colin Brown
Congratulations to Colin who as been chosen by the Physiological Society of NZ (PSNZ) to be the recipient of the NZ Triennial Medal.
28th August, 2017
Dr Andrew Bahn awarded Arthritis NZ Project Grant
Congratulations to Dr Bahn who has been awarded a $60K grant for his project “Identification of oxypurinol transporters to decipher drug-drug interactions in gout treatment”.
25th August, 2017
Congratulations to Lorna Daniels, PhD
Lorna Daniels’ PhD thesis has made the Health Sciences Divisional List of Exceptional Doctoral theses.
14th August, 2017
Professor Colin Brown recognised by the British Society for Neuroendocrinology (BSN)
Prof Brown has been awarded the 2017 Mortyn Jones Memorial Medal, which is awarded annually by the BSN.
30th October, 2017
Dr Alexander Tups (Department of Physiology)
Unless stated otherwise, Departmental Seminars are held in the Hercus D'Ath Lecture Theatre at 13:00 on the day specified.
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Monday, 30th October 2017 - Hercus d'Ath Lecture Theatre at 13:00.
The circadian clock, metabolism and Alzheimer’s disease
Body weight is regulated by the interaction of hormones such as leptin and insulin in the hypothalamus. If the neuronal processing of these hormones is disturbed obesity develops. Interestingly, one consequence of midlife obesity and type 2 diabetes is a higher risk for Alzheimer’s disease which is also referred to as type 3 diabetes by some researchers.
The interaction between the circadian clock and metabolism is a growing research field and working against our clock during our modern lifestyle, e.g. during jetlag and shift-work, has been identified to increase the risk to develop obesity and associated diseases.
Our lab focusses on understanding how the circadian clock e.g. the timing of food affects the central regulation of body weight in order to find the neuroendocrine correlate of the association between circadian timing and obesity. Furthermore, the importance of certain nutrients on neuronal health and on signalling pathways involved in Alzheimer’s disease will be presented.
Monday, 6th November 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Wednesday, 8th November 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Lung liquid clearance and Na+ transport during lung injury: The Titanic paradox.
Every boat has a pump to pump water out. In the lung, Na+ transport is the mechanism for lung liquid clearance at birth and in the adult during pathological events. When the Titanic hit the iceberg you expect the water pumpsto increase their activity. During Acute Respiratory Distress Syndrome there is a loss of barrier integrity leading to an increased permeability and flooding of the interstitial and alveolar space with liquid. Common wisdom would suggest that Na+ transport and liquid clearance should increase in such conditions. Unfortunately, this is in contradiction with our data of the last 20 years. We found that pro-Inflammatory conditions and loss of barrier integrity decrease the expression and activity of the epithelial Na Channel (ENaC) in alveolar epithelial cells. The central question here is how scientific research can transform a paradox into new therapeutic targets?
Monday, 13th November 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Monday, 20th November 2017 - Hercus d'Ath Lecture Theatre at 13:00.
The role of arcuate nucleus kisspeptin neurons in the generation of luteinising hormone pulses
The gonadotropin-releasing hormone (GnRH) neurons are the final output neurons regulating fertility in mammals. GnRH is secreted from the GnRH nerve terminals into the pituitary-portal vasculature and causes the secretion of luteinising hormone (LH) and follicle stimulating hormone (FSH) into the peripheral circulation to regulate gonadal function. GnRH is secreted in a pulsatile manner, and this produces corresponding pulses of LH secretion. In the 1970s the arcuate nucleus (ARN) was identified as being the location of the “GnRH pulse generator”, however, the nature of this pulse generator has remained elusive. Within the ARN lies a population of neurons expressing the neuropeptide kisspeptin (KP), which is critical for fertility in mice and humans, and the dogma has arisen that the ARN KP neurons are the GnRH pulse generator. In the present experiments we have combined a sequential blood collection procedure with transgenic mice and the inhibitory optogenetic tools halorhodopsin (halo) and archaerhodopsin (ArchT) to remotely and reversibly control the activity of the ARN KP neurons and directly probe their role in the generation of LH pulses. Adeno-associated viral vectors (AAVs) were injected bilaterally into the ARN of KP-cre mice to specifically and exclusively target the expression of halo and ArchT to the ARN KP neurons. During the sequential blood sampling procedure, the ARN KP neurons were illuminated with 532nm laser light via an indwelling bilateral fiberoptic cannula for 30min. Illumination with 532nm light, and not 473nm light, resulted in an inhibition in LH secretion for at least the duration of illumination in KP-cre mice expressing either ArchT or halo in ARN KP neurons. Illumination of the ARN KP neurons of wildtype mice injected with the AAVs did not alter LH secretion. Taking advantage of the strong rebound excitation of ARN KP neurons following inhibition with halo, we found that re-setting the activity of the ARN KP neurons resulted in a re-setting of pulsatile LH secretion. These data indicate that the ARN KP neurons are critical for pulsatile secretion of GnRH and LH and likely represent the so-called “GnRH pulse generator”.
Monday, 27th November 2017 - Hercus d'Ath Lecture Theatre at 13:00.
CRP focus group invited speaker
The importance of the pre-systemic circulation in health and disease
Monday, 11th December 2017 - Hercus d'Ath Lecture Theatre at 13:00.
The physiology of today is the medicine of tomorrow.