12th May, 2017
Julia Gouws (MSc student) receives another accolade for her research
After being awarded 1st= for the School of Biomedical Sciences Dean’s Prize for best 2016/17 Summer Scholarship Report recently, Julia has received another prestigious award this week.
5th May, 2017
Physiology PhD students take home prizes at the School Symposium
he School of Biomedical Sciences (BMS) Postgraduate Symposium was held on 3-4 May at the Otago Museum, and once again, our students had great success at the event.
30th March, 2017
Physiology student wins School’s Prize for Best Summer Scholarship report
Congratulations to Julia Gouws (supervisor Dr Karl Iremonger) who was awarded 1st= for the School of Biomedical Sciences Dean’s Prize for best Summer Scholarship Report for 2016/17.
30th March, 2017
Department of Physiology staff continue to be involved in fantastic Lab in a Box initiative
Lab in a Box is a mobile science laboratory, built in a 20 foot shipping container. It comes fully equipped with both science “gear” and people. Researchers and students from around New Zealand (or indeed around the World) are involved in this fantast
9th March, 2017
Anatomy and Physiology at Otago now in the World University Rankings!
Anatomy and Physiology at the University of Otago have ranked 24th in the world in the latest QS World University Rankings.
12th June, 2017
Daniel Barth (PhD Final presentation, Department of Physiology)
Unless stated otherwise, Departmental Seminars are held in the Hercus D'Ath Lecture Theatre at 13:00 on the day specified.
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Monday, 12th June 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Characterising the effect of shear force on the activity of epithelial sodium and acid-sensing ion channels
The epithelial sodium channel (ENaC) is crucial for electrolyte/fluid-homeostasis and blood pressure regulation and its activity is regulated by shear force (SF). Abnormalities in ENaC activity are associated with hypertension. Close relatives to ENaC, and also potential mechanosensitive ion channels involved in the sensation of touch and pain, are the acid-sensing ion channels (ASICs). Whether or not ASICs are able to sense their mechanical environment is unknown. This project aimed to characterise the underlying mechanism of SF sensing by ENaC with a focus on the contribution of the extracellular matrix (ECM). Furthermore, this study aimed to answer whether or not ASICs are regulated by SF.
Monday, 19th June 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Monday, 26th June 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Pseudo(Kinase) signaling and beyond
Post-translational modification of signalling proteins has vast influence on eukaryotic cells, and is frequently disrupted in human disease. In this seminar, I will discuss ongoing research in my laboratory that aims to understand protein signalling mechanisms at the atomic level.
‘Tribbles’ pseudokinases (TRIB1–3) cooperate with the COP1 ubiquitin ligase to regulate transcription factors in various cancers. Our recent TRIB1 structures allow us to propose an integrated mechanism of substrate and COP1 recruitment by TRIB1, which could impact efforts to therapeutically target Tribbles proteins. Similarly, characterisation of the apoptosis signal-regulating kinase family (ASK1–3) has offered new insight into their roles in translating cellular stress signals into coherent MAP kinase signalling. Our studies of ASK and Tribbles proteins will be presented in the context of wider efforts to understand errant protein function across a spectrum of human diseases.
Monday, 3rd July 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Monday, 10th July 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Monday, 17th July 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Monday, 24th July 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Monday, 31st July 2017 - Hercus d'Ath Lecture Theatre at 13:00.
Monday, 14th August 2017 - Hercus d'Ath Lecture Theatre at 13:00.
It's fun getting your hands into the job, e.g. doing experiments on a beating heart. Suddenly all those theories you have been learning about, are made real!