Dr Rebecca Campbell
Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Fax: +64 3 479 7323
Member of Cellular & Molecular Neuroscience.
The Campbell laboratory is part of the University of Otago Centre for Neuroendocrinology.
I am interested in defining how the gonadotrophin releasing hormone (GnRH) neurons, well established as the ultimate downstream regulators of the central control of reproductive function, are regulated by the multitude of external and internal cues necessary for successful fertility. I am investigating the synaptic regulation of GnRH neurons, with particular emphasis on the innervation to their lengthy dendrites, through a variety of morphological imaging and transgenic mouse model approaches. In addition to understanding the regulation of normal fertility, I am also interested in addressing the central neuroendocrine abnormalities of polycystic ovarian syndrome (PCOS), the leading cause of infertility in women.
GnRH neurons, dendrites, synchronization, PCOS
- Exploring the neuroendocrine mechanism of polycystic ovary syndrome (PCOS)
- Investigating the spatial distribution of synaptic inputs to GnRH dendrites
- Mechanisms of pulse generation in the GnRH neuronal network
- 2015-2018, Health Research Council (HRC) Grant, Title: Probing novel pathways mediating PCOS. Principal Investigator ($910,000).
- 2015-2018, Royal Society Marsden Fund, Title: Functional dissection of a novel GABAergic pathway in the brain circuitry controlling fertility. Principal Investigator ($943,000).
- 2012-2017, Health Research Council (HRC) Programme Grant, Title: Neural control of fertility. Joint Principal Investigator (0.10FTE) ($4,935,490). Director: Prof Allan Herbison.
- 2015, University of Otago Research Grant, Title: Putting the pieces together: Getting the bigger picture on fertility regulation - Part II. Principal Investigator ($30,000).
- 2014, University of Otago Research Grant, Title: Putting the pieces together: Getting the bigger picture on fertility regulation. Principal Investigator ($42,085).
- 2011-2014, Health Research Council (HRC) Grant, Title: Investigating the Neuroendocrine Abnormalities of Polycystic Ovarian Syndrome. Principal Investigator (0.2FTE; $650,735).
- 2010-2013, Royal Society Marsden Fund, Title: Primary cilia and the central regulation of fertility. Principal Investigator (0.25FTE; $575,000).
Mauro da Silva
Previous lab personnel
- Katrin Geist
- Galina Gaidamaka
- I Cimino, F Casoni, X Liu, A Messina, J Parkash, SP Jamin, S Catteau-Jonard, F Collier, M Baroncini, D Dewailly, P Pigny, M Prescott, R Campbell, AE Herbison, V Prevot, P Giacobini 2016 Novel role for Anti-Müllerian Hormone in the regulation of GnRH neuron excitability and hormone secretion. Nature Communications 7:10055. (IF:11.5)
- AM Moore, RE Campbell 2015 The neuroendocrine genesis of polycystic ovary syndrome: A role for arcuate nucleus GABA neurons. Journal of Steroid Biochemistry and Molecular Biology S0960-0760(15) 30104-7. (IF: 3.6)
- SH Yip, U Boehm, AE Herbison, RE Campbell 2015 Conditional viral tract-tracing delineates the projections of the distinct kisspeptin neuron populations to gonadotropin-releasing hormone (GnRH) neurons in the mouse. Endocrinology 156:2582-2594. (IF:4.5)
- AM Moore, M Prescott, CJ Marshall, SH Yip, RE Campbell 2015 Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. Proc Natl Acad Sci U S A 112:596-601. (IF: 9.8)
- RE Campbell, AE Herbison 2014 Gonadal steroid neuromodulation of developing and mature hypothalamic neuronal networks. Current Opinion in Neurobiology 29:96-102. (IF: 6.6)
- J Shin, J Mair, M Prescott, RE Campbell 2014 Role for primary cilia in gonadotropin-releasing hormone (GnRH) neurons in the mouse. Journal of Neuroendocrinology 26:18-25. (IF:3.1)
- R Norberg, R Campbell, K Suter 2013 Ion channels and information processing in GnRH neuron dendrites. Channels 7(3): 1-11. (IF: 2.159)
- AM Moore, M Prescott, RE Campbell 2013 Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome. Endocrinology 154:796-806.
- H Chan, M Prescott, Z Ong, MK Herde, AE Herbison, RE Campbell 2011 Dendritic spine plasticity in gonadatropin-releasing hormone (GnRH) neurons activated at the time of the preovulatory surge. Endocrinology 152:4906-4914. (IF: 5.045)
- MK Herde, K Geist, RE Campbell, AE Herbison 2011 Gonadotropin-releasing hormone neurons extend highly complex branched dendritic trees outside the blood-brain-barrier. Endocrinology 152:3832-3841. (IF: 5.045) Featured in “Endocrinology News and Views”
- RE Campbell*, E Ducret*, R Porteous*, X Liu, MK Herde, K Wellerhaus, S Sonntag, K Willecke, and AE Herbison 2011 Gap junctions between neuronal inputs but not gonadotropin-releasing hormone neurons control estrous cycles in the mouse. Endocrinology 152:2290-1301. ( * authors contributed equally) (IF: 5.045) Featured in “US Endocrine News".
- RE Campbell, KJ Suter 2010 Redefining the gonadotrophin-releasing hormone neurone dendrite. Journal of Neuroendocrinology 22:650-658.
- RE Campbell (2007) Young Investigator Perspectives: Defining the gonadotropin-releasing hormone (GnRH) neuronal network: Transgenic approaches to understanding neurocircuitry. Journal of Neuroendocrinology, 19(7): 561-573.
I am passionately devoted to the study of life, and particularly to the higher forms of life. For me the one great question that has dominated my life is: "What am I?" What is the meaning of this marvelous gift of life? The more we know, the more the mystery grows.