Associate Professor Rajesh Katare
Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Fax: +64 3 479 7323
Member of Cardiovascular & Respiratory Physiology.
- Understanding the underlying molecular mechanisms leading to the development of cardiovascular complications in diabetes.
- Role of microRNAs in cardiovascular diseases.
- Development of novel genetic and stem cell therapies for the treatment of ischemic and non-ischemic cardiovascular complications..
microRNA; gene therapy; stem cells; chronic heart failure; Diabetes Mellitus; cardiomyopathy; tissue engineering.
- Pathological role of microRNAs in the development of diabetic cardiomyopathy.
- Circulating microRNAs as potential biomarkers for early diagnosis of cardiovascular complications.
- Gender differences in diabetic heart - why females are more prone to complications.
- Investigating the role of suicidal autophagy in diabetic hearts.
- Treatment of ischemic hearts with resident cardiac stem cells.
- Development of engineered heart tissue using cardiac and induced pluripotent stem cells.
- Lottery Health Board project grant (2015-2017)
- Heart Foundation of New Zealand (2015-2017)
- Heart Foundation of New Zealand (2016-2017)
- University of Otago research grant (2017-2018)
- Royal Society of New Zealand catalyst seed fund (2016-2018)
- Lottery Health Board project grant (2013-2015)
- New Zealand Society for the Study of Diabetes project (Sanofi) grant (2013-2015)
- Maurice & Phyllis Paykel Trust grant-in-aid (2013-2014)
- University of Otago research grant (2013-2014)
- Otago School of Medical Sciences Dean’s Bequest grant (2013-2014)
- Heart Foundation New Zealand small project grant (2012-2013)
- Otago Medical Research Foundation project grant (2012-2013 and 2015-2016)
- • Associate Professor Patrick Manning, Department of Medicine, University of Otago
- Professor Vicky Cameron, Christchurch Heart Institute, University of Otago
- Professor Michael Williams, Department of Medicine, University of Otago
- Professor Paolo Madeddu, Bristol Heart Institute, University of Bristol, United Kingdom
- Professor Costanza Emanueli, Bristol Heart Institute, University of Bristol, United Kingdom
- Professor Saadeh Suleiman, Department of Cardiovascular Physiology, University of Bristol, United Kingdom
- A/P Antonio Beltrami, Department of Pathology, University of Udine, Italy
- Professor Sato Takayuki, Department of Physiology, Kochi University, Japan
- Prof Kakinuma Yoshihiko, Department of Physiology, Nippon Medical School, Japan
- Professor Ando Motonori, Laboratory of Cell Physiology, Department of Science Education, Okayama University, Japan
- Satthenapalli VR, Lamberts RR, Katare R. Challenges in regenerating the diabetic heart – A comprehensive review. Stem cells, 2017, DOI:10.1002/stem.2661.
- Rawal S, Munasinghe PE, Thevakar P, Lew JK, Jones GT, Williams MJ, Davis P, Bunton RW, Galvin IF, Manning P, Lamberts RR, Katare R. Downregulation of miR-15a/b accelerates fibrotic remodelling in the type-2 diabetic human and mouse heart. Clin Sci (Lond). 2017 May 1; 131(9): 847-863.
- Ram TP, Fomison-Nurse I, Gandhi S, Coffey S, Saxena P, Galvin I, Bunton R, Williams MJ, Lamberts RR, Katare R. The diagnostic sensitivity of circulating cardio-enriched microRNAs is increased after normalization of high-density lipoprotein levels. Int J Cardiol. 2017 Jun 1; 236: 498-500.
- Lew JK, Pearson JT, Schwenke DO*, Katare R*. Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways. Cardiovasc Diabetol. 2017 Jan 13; 16(1): 10. *Equal contribution.
- Rawal S, Munasinghe PE, Shindikar A, Paulin J, Cameron V, Manning P, Williams MJ, Jones GT, Bunton R, Galvin I, Katare R. Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovasc Res. 2017 Jan;113(1):90-101.
- Dixit P, Donnelly H, Edamatsu M,Galvin I, Katare R. Progenitor cells from atria, ventricle and peripheral blood of the same patients exhibit functional differences associated with cardiac repair. Int J Cardiol. 2017;228:412-421.
- Katare R, Rawal S, Munasinghe PE, Tsuchimochi H, Inagaki T, Fujii Y, Dixit P, Umetani K, Kangawa K, Shirai M, Schwenke DO. Ghrelin Promotes Functional Angiogenesis in a Mouse Model of Critical Limb Ischemia Through Activation of Proangiogenic MicroRNAs. Endocrinology. 2016 Feb; 157(2): 432-445.
- Rawal S, Ram TP, Coffey S, Williams MJ, Saxena P, Bunton RW, Galvin IF, Katare R. Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction. Int J Cardiol 2016. 202; 38–40 (IF – 6.2).
- Munasinghe PE, Riu F, Dixit P, Edamatsu M, Saxena P, Hamer NSJ, Galvin IF, Bunton RW, Lequeux S, Jones G, Lamberts RR, Emanueli C, Madeddu P, Katare R. Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. Int J Cardiol 2016. 202; 13–20.
- Caporali A, Meloni M, Nailor A, Mitić T, Shantikumar S, Riu F, Sala-Newby GB, Rose L, Besnier M, Katare R, Voellenkle C, Verkade P, Martelli F, Madeddu P, Emanueli C. p75 NTR-dependent activation of NF-kB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb-ischemia. Nature Commun. 2015. 13; 6: 8024.
- Avolio E, Meloni M, Spencer HL, Riu F, Katare R, Mangialardi G, et al., Combined Intramyocardial Delivery of Human Pericytes and Cardiac Stem Cells Additively Improves the Healing of Mouse Infarcted Hearts Through Stimulation of Vascular and Muscular Repair. Circ Res. 2015 Mar; 116(10): e81-94.
- Dixit P and Katare R. Identifying the source of stem cells in cardiac regeneration therapy. Stem Cell Res Ther. 2015. 6(1): 26.
- Purvis N, Bahn A, Katare R. The role of microRNAs in cardiac stem cells. Stem Cells Int. 2015; 194894: 1-10.
- Avolio E, Gianfranceschi G, Cesselli D, Caragnano A, Athanasakis E, Katare R, Meloni M, Finato N, Aresu G, Livi U, Emanueli C, Scoles G, Beltrami CA, Madeddu P, Beltrami AP. Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction. Stem Cells. 2014; 2(9): 2373-85 May 6.
- Moore A, Shindikar A, Riu F, Fomison-Nurse I, Saxena P, Munasinghe PE, Parshuram T, Bunton RW, Galvin IF, Emanueli C, Madeddu P, Katare R. Rapid onset of cardiomyopathy in diabetic female mice involves the downregulation of pro-survival pim-1 kinase. Cardiovasc Diabetol. 2014; 13(1):68.
- Lamberts RR, Lingam SJ, Wang HY, Bollen IA, Hughes G, Galvin IF, Bunton RW, Bahn A, Katare R, Baldi JC, Williams MJ, Saxena P, Coffey S, Jones PP. Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovasc Diabetol. 2014; 13: 72.
- Rawal S, Manning P, Katare R. Cardiovascular micrornas: As modulators and diagnostic biomarkers of diabetic heart disease. Cardiovasc Diabetol. 2014 Feb 14; 13(1): 44.
- Katare R, Stroemer P, Hicks C, Stevanato L, Patel S, Corteling R, Miljan E, Vishnubhatla I, Sinden J, Madeddu P. Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arterioscler Thromb Vasc Biol. 2014; 34(2): 408-418.
- Katare R, Riu F, Rowlinson J, Lewis A, Holden R, Meloni M, Reni C, Wallrapp C, Emanueli C, Madeddu P. Perivascular Delivery of Encapsulated Mesenchymal Stem Cells Improves Postischemic Angiogenesis Via Paracrine Activation of VEGF-A. Arteriosclerosis Thrombosis and Vascular Biology, 2013; 33(8): 1872-1880.
- Katare R, Oikawa A, Cesselli D, Beltrami AP, Avolio E, Muthukrishnan D, Munasinghe PE, Angelini G, Emanueli C, Madeddu P. Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes. Cardiovascular Research, 2013;97(1):55-65.
- Amadesi S, Reni C, Katare R, Meloni M, Oikawa A, Beltrami AP, Avolio E, Cesselli D, Fortunato O, Spinetti G, Ascione R, Cangiano E, Valgimigli M, Hunt SP, Emanueli C, Madeddu P. Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects. Circulation, 2012;125(14):1774-1786.
- Course Covenor – PHSL344
- ELM2 (Medicine 2nd year) – Vascular Physiology
- PHSL232 (Respiratory Physiology)
- PHSL471 (Research Topic)
My Summer Research Scholarship in the Department of Physiology was the highlight of my time at the University of Otago as I learnt many new skills, including how to carry out scientific research in a controlled manner, collecting and analyzing scientific data in an orderly fashion, and most importantly, learning to read and think critically.
For more information on the Summer Research Programme, click here