Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Phone: 479 4862
Fax: +64 3 479 7323
Member of Cellular & Molecular Neuroscience.
Keywords: gene therapy, nutritional interventions, obesity, metabolic disorders
Project Grant by the German Research Foundation (DFG): 2014-2016 http://gepris.dfg.de/gepris/OCTOPUS?context=person&id=201192876&task=generateDetailPDF
German Ministry of Education and Research (2008-2013) http://www.gesundheitsforschung-bmbf.de/de/5345.php
Boehringer Ingelheim Fonds (2003-2005)
Williams LM, Campbell FM, Drew JE, Koch C, Hoggard N, Rees WD, Kamolrat T, Thi Ngo H, Steffensen IL, Gray SR, Tups A. The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases. PLoS One. 2014 Aug 29;9(8): e106159.
Penzkofer D, Bonauer A, Fischer A, Tups A, Brandes RP, Zeiher AM, Dimmeler S. Phenotypic characterization of miR-92a-/- mice reveals an important function of miR-92a in skeletal development. PLoS One. 2014 Jun 30; 9(6): e101153. doi: 10.1371/journal.pone.0101153. eCollection 2014.
Briggs DI, Lockie SH, Benzler J, Wu Q, Stark R, Reichenbach A, Hoy AJ, Lemus MB, Coleman HA, Parkington HC, Tups A, Andrews ZB. Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice. Endocrinology. 2014 Jul;155(7):2411-22.
Koch CE, Lowe C, Legler K, Benzler J, Boucsein A, Böttiger G, Grattan DR, Williams LM, Tups A. Central adiponectin acutely improves glucose tolerance in male mice. Endocrinology. 2014 May;155(5): 1806-16.
Koch CE, Lowe C, Pretz D, Steger J, Williams LM, Tups A. High-fat diet induces leptin resistance in leptin-deficient mice. J Neuroendocrinol. 2014 Feb; 26(2): 58-67.
Benzler J, Andrews ZB, Pracht C, Stöhr S, Shepherd PR, Grattan DR, Tups A. Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice. Endocrinology. 2013 Dec; 154(12): 4737-45.
Ganjam GK, Benzler J, Pinkenburg O, Boucsein A, Stöhr S, Steger J, Culmsee C, Barrett P, Tups A. Overexpression of suppressor of cytokine signaling 3 in the arcuate nucleus of juvenile Phodopus sungorus alters seasonal body weight changes. J Comp Physiol B. 2013 Dec; 183(8): 1101-11.
Benzler J, Ganjam GK, Legler K, Stöhr S, Krüger M, Steger J, Tups A. Acute inhibition of central c-Jun N-terminal kinase restores hypothalamic insulin signalling and alleviates glucose intolerance in diabetic mice. J Neuroendocrinol. 2013 May; 25(5): 446-54.
Koch CE, Ganjam GK, Steger J, Legler K, Stöhr S, Schumacher D, Hoggard N, Heldmaier G, Tups A. The dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signalling. Br J Nutr. 2013 Mar 28; 109(6): 1040-51.
Benzler J, Ganjam GK, Krüger M, Pinkenburg O, Kutschke M, Stöhr S, Steger J, Koch CE, Ölkrug R, Schwartz MW, Shepherd PR, Grattan DR, Tups A. Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism. Biochem J. 2012 Oct 1; 447(1): 175-84.
Koch CE, Göddeke S, Krüger M, Tups A. Effect of central and peripheral leucine on energy metabolism in the Djungarian hamster (Phodopus sungorus). J Comp Physiol B. 2013 Feb; 183(2): 261-8.
Tups A, Stöhr S, Helwig M, Barrett P, Krol E, Schachtner J, Mercer JG, Klingenspor M. Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein. J Comp Physiol B. 2012 May; 182(4): 553-67.
Koch C, Augustine RA, Steger J, Ganjam GK, Benzler J, Pracht C, Lowe C, Schwartz MW, Shepherd PR, Anderson GM, Grattan DR, Tups A. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. J Neurosci. 2010 Dec 1; 30(48): 16180-7.
I believe the best way to grow as a scientist is to be thrown in the deep end early on. My summer projects gave me this opportunity in a safe and fun environment, so when I started my thesis research I was already familiar with the scientific method. Having finished my PhD, I also really appreciate the boost they give my academic CV!