Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Phone: 479 7300
Fax: +64 3 479 7323
Member of Cellular & Molecular Neuroscience.
Member of the Cellular and Molecular Neuroscience group and the Centre for Neuroendocrinology
The hypothalamus is an area of the brain that contains neural circuits that are essential for survival. We are specifically interested in one part of the hypothalamus called the paraventricular nucleus (PVN). Neurons in the PVN are activated in response to many different types of stress and in turn release neuropeptides both within the brain and into the circulation to control the body’s stress response.
We use electrophysiology, imaging, optogenetics and other techniques to understand how neural circuits within the PVN function. We are specifically interested in determining how stress responsive neurons in the PVN process information and adapt across different physiological and behavioral states.
Herde MK*, Iremonger KJ*, Constantin S and Herbison AE. GnRH neurons elaborate a long-range projection with shared axonal and dendritic functions. Journal of Neuroscience. 2013; 33(31): 12689-97. *co-first authors
Iremonger KJ*, Wamsteeker Cusulin JI* and Bains JS. Changing the tune: Plasticity and adaptation of retrograde signals. Trends in Neurosciences. 2013; 36(8): 471-9. *co-first authors IF = 13.4, 5 citations.
Constantin S, Iremonger KJ and Herbison AE. In vivo recording of GnRH neuron firing reveal heterogeneity and dependence on GABA receptor signalling. Journal of Neuroscience. 2013; 33(22): 9394-401.
Chen X, Iremonger K, Herbison A, Kirk V, Syned J. Regulation of bursting in a spatiotemporal model of a GnRH neuron. Bulletin of Mathematical Biology. 2013; 75 (10): 1941-60.
Iremonger KJ, Herbison AE. Initiation and propagation of action potentials in GnRH neuron dendrites. Journal of Neuroscience. 2012; 32(1): 151-8.
Constantin S, Piet R, Iremonger K, Yeo SH, Clarkson J, Porteous R and Herbison AE. Gonadotropin-releasing hormone neuron firing and response to GABA depends on acute brain slice orientation. Endocrinology. 2012; 153(8): 3758-69.
Iremonger KJ, Kuzmiski JB, Baimoukhametova DV, Bains JS. Dual regulation of anterograde and retrograde transmission by endocannabinoids. Journal of Neuroscience. 2011; 31(33): 12011-20.
Iremonger KJ, Constantin S, Liu X, Herbison AE. Glutamate regulation of GnRH neuron excitability. Brain Research. 2010; 1364: 35-43.
Iremonger KJ, Benediktsson AM, Bains JS. Glutamatergic synaptic transmission in neuroendocrine cells: Basic principles and mechanisms of plasticity. Frontiers in Neuroendocrinology. 2010; 31(3): 296-306.
Gordon GR, Iremonger KJ, Kantevari S, Ellis-Davies GC, MacVicar BA, Bains JS. Astrocyte-mediated distributed plasticity at hypothalamic glutamate synapses. Neuron. 2009; 64(3): 391-403.
Iremonger KJ, Bains JS. Retrograde opioid signaling regulates glutamatergic transmission in the hypothalamus. Journal of Neuroscience. 2009; 29(22): 7349-58.
Iremonger KJ and Bains JS. Dynamic synapses in the hypothalamic-neurohypophyseal system. Progress in Brain Research, 2008; 170: 119-28. Iremonger KJ and Bains, JS. Integration of asynchronously released quanta prolongs the postsynaptic spike window. Journal of Neuroscience 2007; 27(25): 6684-91.
Iremonger KJ, Anderson TR, Hu B and Kiss ZHT. Cellular mechanisms preventing sustained activation of cortex during subcortical high frequency stimulation. Journal of Neurophysiology 2006; 96(2): 613-21.
Anderson TR, Hu B, Iremonger K and Kiss ZHT. Selective attenuation of afferent synaptic transmission as a mechanism of thalamic deep brain stimulation-induced tremor arrest. Journal of Neuroscience 2006; 26(3): 841-850.
The physiology of today is the medicine of tomorrow.