Dr Jeff Erickson
Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Fax: +64 3 479 7323
Member of Cardiovascular & Respiratory Physiology.
My research focuses on investigating the mechanisms that underlie heart failure and vascular disease particularly in the context of hypertension and diabetes. To this end, we have developed a number of novel tools to assess cardiovascular signaling pathways.
- FRET-based biosensors to measure kinase activity and localization in living cells
- custom antibodies to measure biochemical modifications of proteins
- a variety of animal models with enhanced or reduced susceptibility to cardiovascular pathology.
With this research, we hope to contribute new understanding to the molecular basis of cardiovascular signaling that will culminate in potential clinical therapies for heart disease and atherosclerosis.
- Identifying the mechanism by which CaMKII regulates cellular signaling in the diabetic heart
- The role of CaMKII in vascular physiology and pathology
- Nitric oxide as a mediator of cardiac signaling
- Health Research Council Project Grant
- Royal Society of New Zealand Marsden Fast Start Research Grant
- University of Otago Research Grant
- American Heart Association Scientist Development Grant
- National Institute of Health T32 Fellowship
- Erickson JR, Nichols CB, Uchinoumi H, Stein ML, Bossuyt J, Bers DM. S-Nitrosylation induces both autonomous activation and inhibition of calciumcalmodulin dependent protein kinase II delta. J Biol Chem. (2015). 290:25646-56.
- Daniels L, Bell JR, Delbridge LM, McDonald FJ, Lamberts RR, Erickson JR. The role of CaMKII in diabetic heart dysfunction. Heart Fail Rev. (2015) 20:589-600.
- Grimm M, Ling H, Pereira L, Willeford A, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH. CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca2+ leak and the pathophysiological response to chronic β-adrenergic stimulation. J Mol Cell Cardiol. (2015) pii: S0022-2828(15)00193-5.
- Pereira L, Rehmann H, Lao DH, Erickson JR, Bossuyt J, Chen J, Bers DM. Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes. PNAS. (2015) 10.1073.
- Bell JR, Raaijmakers AJ, Curl CL, Reichelt ME, Harding TW, Bei A, Ng DC, Erickson JR, Vila Petroff M, Harrap SB, Delbridge LM. Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. Int J Cardiol. (2014) 181C:288-296.
- Bell JR, Erickson JR, Delbridge LM. Ca(2+) /calmodulin dependent kinase II: a critical mediator in determining reperfusion outcomes in the heart? Clin Exp Pharmacol Physiol. (2014) 41:940-6.
- Erickson JR. Mechanisms of CaMKII Activation. Frontiers in Pharmacology Research. (2014) 5:59.
- Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. (2014) 7:ra27.
- Zhang DM, Chai Y, Erickson JR, Heller Brown J, Bers DM, Lin YF. Modulation of Sarcolemmal ATP-Sensitive Potassium Channels by Nitric Oxide via sGC/PKG/ROS/ERK1/2/CaMKII Signaling in Ventricular Cardiomyocytes. Journal of Physiology. (2014) 592:971-90.
- Erickson JR, Patel R, Ferguson A, Bossuyt J, Bers DM. FRET-based sensor Camui provides new insight into mechanisms of CaMKII activation in intact cardiomyocytes. Circulation Research. (2011) Sep 16;109(7):729-38.
- Erickson JR, He B, Grumbach I, Anderson ME. CaMKII in the Cardiovascular System: Sensing Redox States. Physiological Reviews. (2011) Jul;91(3):889-915.
- Erickson JR, Anderson ME. CaMKII and its role in cardiac arrhythmia. Journal of Cardiovascular Electrophysiology. (2008) Dec;19(12):1332-6.
- Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. (2008) 133(3): 462-74.
HUBS 192 Human Body Systems II
PHSL 344 Cardiovascular & Respiratory Physiology