University of Otago.Department of Physiology.Department of Physiology.

McDonald Lab

Associate Professor Fiona McDonald

Fiona McDonald

Associate Professor/Deputy HoD (Teaching)

Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Dunedin
New Zealand

Phone: 4797329
Fax: +64 3 479 7323

Email: fiona.mcdonald@otago.ac.nz

Member of Membrane & Ion Transport.

Member of research themes "Functional Genomics, Gene Expression and Proteomics" and Kidney in Health and Disease.

Research interests

How do proteins find their way to their correct location in a cell? What factors control this "protein trafficking" process? Using the epithelial sodium channel (ENaC), essential for kidney control of blood pressure, we have shown that ubiquitin pathway proteins control the number of ENaCs at the cell surface resulting in changes in Na+ absorption. As part of a protein interaction screen we discovered that COMMD family proteins also regulate ENaC trafficking. The mechanisms and implications of this pathway are under investigation.

Pancreatic acinar cells are responsible for digestive enzyme secretion subsequently necessary for breakdown of ingested food. Unregulated activation of digestive enzymes in the acinar cells of the pancreas can cause cell damage, in a process called pancreatitis. The COMMD10 protein is highly expressed in pancreas and has links to the protein secretory pathway; we are currently investigating the role of COMMD10 in the production and secretion of digestive enzymes from pancreatic acinar cells.

Expertise

Projects

Current funding

Collaborators

Lab personnel

Joshua April

Joshua April

Tanya Cheung

Tanya Cheung

Sama Mugloo

Sama Mugloo

Sahib Rasulov

Sahib Rasulov

Monique Scott

Monique Scott

Adam Ware

Adam Ware


Previous lab personnel

Selected publications

Teaching

Joshua April

Joshua April

PGDipSci Student

Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Dunedin
New Zealand

Phone: 479 7316
Fax: +64 3 479 7323

Email: aprjo818@student.otago.ac.nz

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Tanya Cheung

Tanya Cheung

Assistant Research Fellow

Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Dunedin
New Zealand

Phone: 4796371
Fax: +64 3 479 7323

Email: tanya.cheung@otago.ac.nz

Show McDonald Lab page.

Sama Mugloo

Sama Mugloo

PhD Student

Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Dunedin
New Zealand

Phone: 479 6371
Fax: +64 3 479 7323

Email: mugsa771@student.otago.ac.nz

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Sahib Rasulov

Sahib Rasulov

PhD Student

Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Dunedin
New Zealand

Phone: 479 6371
Fax: +64 3 479 7323

Email: rasah673@student.otago.ac.nz

Show McDonald Lab page.

Monique Scott

Monique Scott

PGDipSci

Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Dunedin
New Zealand

Phone: 479 7316
Fax: +64 3 479 7323

Email: scomo001@student.otago.ac.nz

Show McDonald Lab page.

Adam Ware

Adam Ware

Assistant Research Fellow/PhD Student

Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Dunedin
New Zealand

Phone: 479 6371
Fax: +64 3 479 7323

Email: warad375@student.otago.ac.nz

Show McDonald Lab page.

I am passionately devoted to the study of life, and particularly to the higher forms of life. For me the one great question that has dominated my life is: "What am I?" What is the meaning of this marvelous gift of life? The more we know, the more the mystery grows.

Sir John Eccles - The Nobel Prize in Physiology or Medicine 1963