Dr Regis Lamberts
Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Fax: +64 3 479 7323
Member of Cardiovascular & Respiratory Physiology.
How the heart maintains its function under conditions of stress has been the major focus of my research career. My current research aims to determine the unknown changes in autonomic regulation of heart function in obesity and diabetes by generating biomedical data at the cellular and organ level, and obtaining functional human myocardial and clinical data through HeartOtago. This translational knowledge creates the platform that is vital for the development of more specific therapeutics for the increasing cohort of individuals with obesity and diabetes to improve their heart health.
- Obesity, Diabetes, Pulmonary Hypertension, Ischemia, Hypertrophy and Heart Failure models.
- In vivo blood pressure measurements with radiotelemetry transmitters
- In vivo stress-free drug administration through implanted vascular access ports
- Ex vivo isolated Langendorff-perfused hearts for simultaneous LV and RV pressure and coronary flow measurements
- Ex vivo isolated cardiac muscles (papillary muscles, trabeculae)
- How fat makes the heart fibrillate; Heart Foundation (PI)
- Myoregulin: a secret code underlying heart disease; OMS Collaborative Research Grant (PI)
- Unravelling the secrets of the b-adrenoceptors in the human diabetic heart; OMRF (PI)
- CaMKII inhibition as a novel therapy for diabetic cardiomyopathy; Health Research Council (HRC) (AI)
Genetic engineering of cardiac stem cells for the therapeutic regeneration of the diabetic heart; Heart Foundation NZ (co-PI)
- Lottery Health Research (2014)
- HealthCare Otago Charitable Trust NZ (2013 and 2011)
- University of Otago Research grant (2012 and 2014)
- Heart Foundation NZ (2012)
- OMRF Laurenson Award NZ (2012)
Isabelle van Hout
- β-adrenergic responsiveness in the type 2 diabetic heart: effects on cardiac reserve. GA Wilson, LC Wilson, RR Lamberts, K Majeed, S Lal, GT Wilkins, JC Baldi. Medicine & Science in Sports & Exercise, in press 2017.
- The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. JC Baldi, GA Wilson, LC Wilson, GT Wilkins, RR Lamberts. Sports Medicine, 46(11): 1605-1617, 2016.
- Increased cardiac SNA and reduced cardiac functional responsiveness in Zucker Diabetic Fatty rats. HPA Thaung, JC Baldi, HY Wang, RF Cook, G Hughes, CT Bussey, PS Sheard, PP Jones, A Bahn, DO Schwenke, RR Lamberts. Diabetes 64(8) 2944-2956, 2015.
- Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. CT Bussey, G Hughes, P Saxena, IF Galvin, RW Bunton, MK Noye, S Coffey, MJA Williams, JC Baldi, PP Jones, RR Lamberts. International Journal of Cardiology 193: 53-55, 2015.
- Chronic bilateral renal denervation reduces cardiac hypertrophic remodeling but not b-adrenergic responsiveness in the hypertensive type 1 diabetic rat. HPA Thaung, Y Yao, CT Bussey, G Hughes, PP Jones, A Bahn, IA Sammut, and RR Lamberts. Experimental Physiology 100.6:628-639, 2015.
- The role of CaMKII in diabetic heart dysfunction. L Daniels, JR Bell, LM Delbridge, FJ McDonald, RR Lamberts, JE Erickson. Heart Failure Reviews, 20(5):589-600, 2015.
- Cardiovascular control during exercise in type 2 diabetes mellitus. S Green, M Egana, JC Baldi, RR Lamberts, JG Regensteiner. Experimental Diabetes Research (J Diabetes Research), 2015: 654204, 2015.
- Type 2 diabetes increases autophagy in the human heart through promotion of beclin-1 mediated pathway. PE Munasinghe, F Riu, P Dixit, M Edamatsu, P Saxena, NSJ Hamer, IF Galvin, RW Bunton, S Lequeux, G Jones, RR Lamberts, C Emanueli, P Madeddu, R Katare. International Journal of Cardiology, 202:13-20, 2015.
- Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice. N Jahn, RR Lamberts, CJ Busch, MT Voelker, T Busch, MJA Koel-Simmelink, CE Teunissen, DD Oswald, SA Loer, UX Kaisers, J Weimann. Respiratory Research 2015, in press.
- Increased hemodynamic adrenergic load with isoflurane anesthesia in type 2 diabetic and obese rats in vivo. CT Bussey, AE de Leeuw, RR Lamberts. Cardiovascular Diabetology 13:161. 2014.
- Impaired relaxation despite upregulated calcium-handling proteins in atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Lamberts RR, Lingam SJ, Wang HY, Bollen IAE, Hughes G, Saxena P, Galvin IF, Bunton RW, Bahn A, Katare R, Baldi JC, Williams MJA, Coffey S, Jones PP. Cardiovascular Diabetology, 13:72-83, 2014.
- Dual Implantation of a Radio-Telemeter and Vascular Access Port allows repeated conscious hemodynamic and pharmacological measures in lean and obese rats. Bussey CT, de Leeuw AE, Cook RF, Ashley Z, Schofield J, Lamberts RR. Laboratory Animals, 48(3): 250-260, 2014.
- Mechanical ventilation with high tidal volumes attenuates myocardial dysfunction by decreasing cardiac edema in a rat model of LPS-induced peritonitis. Smeding L, Plotz FB, Lamberts RR, van der Laarse WJ, Kneyber MC, Groeneveld JA. Respir Res. 2012 Mar 20;13(1):23.
- Early Myocardial Dysfunction is not Caused by Mitochondrial Abnormalities in a Rat Model of Peritonitis. Smeding L, van der Laarse WJ, van Veelen TA, Lamberts RR, Niessen HWM, Kneyber MCJ, Groeneveld ABJ, Plötz FB. Journal of Surgical Research. 2011. DOI: 10.1016/j.jss.2011.05.055, 2011.
- Effect of bupivacaine on sevoflurane-induced cardioprotection after ischemia-reperfusion in isolated rat hearts. Bouwman RA, Vreden MJA, Wassenaar LEJ, den Oudsten GG, Loer SA, Stienen GJM, Lamberts RR. European Journal of Pharmacology. 2010. 647(1-3): 132-138.
- Altered jugular vein and ductus venosus flow velocities in fetuses with increased nuchal translucency and distended jugular lymphatic sacs. de Mooij YM, Bartelings MM, Twisk JW, Lamberts RR, Gittenberger-de Groot AC, van Vugt JM, Bekker MN. Am J Obstet Gynecol. 2010. 202(6):566.e1-8.
- Reactive oxygen species-induced stimulation of 5'AMP-activated protein kinase mediates sevoflurane-induced cardioprotection. Lamberts RR, Onderwater G, Hamdani N, Vreden MJ, Steenhuisen J, Eringa EC, Loer SA, Stienen GJ, Bouwman RA. Circulation. 2009. 120(11 Suppl):S10-5.
- Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart. Handoko ML, Lamberts RR, Redout EM, de Man FS, Boer C, Simonides WS, Paulus WJ, Westerhof N, Allaart CP, Vonk-Noordegraaf A. Am J Physiol Heart Circ Physiol. 2009. 297(5):H1752-9.
- Sevoflurane-induced cardioprotection depends on PKC-alpha activation via production of reactive oxygen species. Bouwman RA, Musters RJ, van Beek-Harmsen BJ, de Lange JJ, Lamberts RR, Loer SA, Boer C. Br J Anaesth. 2007. 99(5):639-45.
- Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats. Lamberts RR, Caldenhoven E, Lansink M, Witte G, Vaessen RJ, St Cyr JA, Stienen GJ. Am J Physiol Heart Circ Physiol. 2007. 293(3):H1869-76.
- Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. Lamberts RR, Hamdani N, Soekhoe TW, Boontje NM, Zaremba R, Walker LA, de Tombe PP, van der Velden J, Stienen GJ. J Physiol. 2007. 582(Pt 2):695-709.
- Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat. Lamberts RR, Vaessen RJ, Westerhof N, Stienen GJ. Basic Res Cardiol. 2007. 102(1):19-27.
- Cross-talk between cardiac muscle and coronary vasculature. Westerhof N, Boer C, Lamberts RR, Sipkema P. Physiol Rev. 2006. 86(4):1263-308. Review.
- Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium. van der Velden J, Narolska NA, Lamberts RR, Boontje NM, Borbély A, Zaremba R, Bronzwaer JG, Papp Z, Jaquet K, Paulus WJ, Stienen GJ. Cardiovasc Res. 2006. 69(4):876-87.
- PHSL490 - (Research Project)
- PHSL471 - (Systematic Physiology)
- PHSL344 - Lectures (Cardiovascular function in Diabetes)
- PHSL344 - Labs (Cardiac function and Seminars)
- PHSL232 - Lectures (Basic Cardiac function, Hypertension and Obesity)
- PHSL232 - Labs (Cardiac Contraction)
- HUBS191 - Lectures (Muscle types)
- PHSL232 - Course Convener
I believe the best way to grow as a scientist is to be thrown in the deep end early on. My summer projects gave me this opportunity in a safe and fun environment, so when I started my thesis research I was already familiar with the scientific method. Having finished my PhD, I also really appreciate the boost they give my academic CV!
For more information on the Summer Research Programme, click here