Dr Peter Jones
Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Fax: +64 3 479 7323
Member of Cardiovascular & Respiratory Physiology and Membrane & Ion Transport.
My principal research interest is in how calcium cycling is controlled in cardiac myocytes. In particular, my focus is on the mechanisms by which calcium release from intra-cellular stores (sarcoplasmic reticulum, SR) is controlled by the cardiac ryanodine receptor (RyR2). The aim of my research is to characterize how the activity of RyR2 is altered both physiologically and in disease. This is achieved using a broad spectrum of assays from molecular biology and single channel recordings, through to isolated cardiac myocytes and ultimately whole animal models.
Arrhythmia, RyR2, calcium, sarcoplasmic reticulum, RyR1, malignant hyperthermia
- 2015-2017, Heart Foundation of New Zealand
- 2015, Lottery Health Equipment Grant
- 2014-2015, University of Otago Research Grant
- 2013, Healthcare Otago Trust
- 2013, Heart Foundation of New Zealand
- 2012-2013, Otago Medical Research Foundation, Laurenson Award
- 2011-2014, Royal Society of New Zealand Marsden Fund
- 2011-2012, Lottery Health Research
Badrilla Ltd, www.badrilla.com (characterisation of phosphor-specific cardiac antibodies)
Isabelle van Hout
Publications (last 5 years)
- Waddell, H.M.M., Zhang, J.Z., Hoeksema, K.J., McLachlan, J.J., McLay, J.C., Jones, P.P. (2016). Oxidation of RyR2 Has a Biphasic Effect on the Threshold for Store Overload-Induced Calcium Release. Biophysical Journal (in press)
- Zhang, J.Z., Waddell, H.W.W., Wu, E., Dholakia, J., Okolo, C.A., Janet C McLay, Jones, P.P. (2016). FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2. Biochemical Journal (in press)
- Diong, C., Jones, P.P., Tsuchimochi, J., Gray, E.A., Hughes, G., Inagaki, T., Bussey, C.T., Fujii, Y., Umetani, K., Shirai, M., Schwenke, D.O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: physiological relevance to the ‘obesity paradox’. International Journal of Obesity (in press)
- Thaung HP, Baldi JC, Wang HY, Hughes G, Cook RF, Bussey CT, Sheard PW, Bahn A, Jones PP, Schwenke DO, Lamberts RR. Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes (in press)
- Bussey CT, Hughes G, Saxena P, Galvin IF, Bunton RW, Noye MK, Coffey S, Williams MJ, Baldi JC, Jones PP*, Lamberts RR*. (2015) Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. Int. J. Cardiol. 193:53-55 (*co-corresponding authors).
- Thaung HP, Yao Y, Bussey CT, Hughes G, Jones PP, Bahn A, Sammut IA, Lamberts RR. (2015) Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β‐adrenergic responsiveness in hypertensive type 1 diabetic rats. Exp. Physiol. 100(6):628-39.
- Liu Y, Sun B, Xiao Z, Wang R, Guo W, Zhang JZ, Mi T, Wang Y, Jones PP, Van Petergem F, Chen SR. (2015) Roles of the NH2-terminal Domains of Cardiac Ryanodine Receptor in Ca2+ Release Activation and Termination. J. Biol. Chem. 290(12):7736-46.
- Mi T, Xiao Z, Guo W, Tang Y, Hiess F, Xiao J, Wang Y, Zhang JZ, Zhang L, Wang R, Jones PP, Chen SR. (2015) Role of Cysteine-3602 in the Function and Regulation of the Cardiac Ryanodine Receptor. Biochem. J. 497(1):177-190.
- Zhang JZ, Waddell HMM, Jones PP. (2015) Regulation of RyR2 by Sarcoplasmic Reticulum Ca2+. Clin. Exp. Pharmacol. Physiol. 42(6):720-26.
- Zhang JZ, McLay JC, Jones PP. (2014) The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca2+ release due to an impaired ability to buffer store Ca2+. J. Mol. Cell. Cardiol. 74C:22-31.
- Lamberts RR, Lingam SJ, Wang HY, Bollen IA, Hughes G, Galvin IF, Bunton RW, Bahn A, Katare R, Baldi JC, Williams MJ, Saxena P, Coffey S, Jones PP. (2014) Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovasc Diabetol. 13:72.
- Chen W, Wang R, Chen B, Zhong X, Kong H, Bai B, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, et al. (2014) The Ryanodine Receptor Store Sensing Gate Controls Ca2+ Waves and Ca2+ Triggered Arrhythmias. Nat. Med. 20(2):184-92.
- Bai Y*, Jones PP*#, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song L-S, Duff HJ, Chen SR#. (2013) Phospholamban Knockout Breaks Arrhythmogenic Ca2+ Waves and Suppresses Catecholaminergic Polymorphic Ventricular Tachycardia in Mice. Circ. Res. 113(9):517-26 (*Co-first, #co-corresponding authors).
- Liu Y, Kimlicka L, Hiess F, Tian X, Wang R, Zhang L, Jones PP, van Petegem F, Chen SR. (2013) The CPVT-associated RyR2 Mutation G230C Enhances Store Overload-Induced Ca2+ Release and Destabilizes the NH2-terminal domains. Biochem. J. 15;454(1):123-31.
- Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones PP, Tian X, Wilson LS, Ahmad F, Chen SR, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH. (2011) Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca2+ Release and Cardiac Contractility, Independently of L-Type Ca2+ Current. Circ. Res., 109(9):1024-30.
- Zhou Q, Xiao J, Jiang J, Wang R, Vembaiyan V, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song L-S, Fill M, Back TG & Chen SRW. (2011) Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat. Med. 17:1003-1009.
- Wang, R., Zhong, X., Meng, X., Koop, A., Tian, X., Jones, P.P., Fruen, B.R., Wagenknecht, T., Liu, Z., & Chen, S.R.W. (2011). Localization of the dantrolene binding sequence near the FKBP binding site in the three-dimensional structure of the ryanodine receptor. Journal of Biological Chemistry, 286(14): 12202-12..
- Mufti RE, Brett SE, Tran CHT, El-Rahman RA, Anfinogenova Y, El-Yazbi A, Cole WC, Jones PP, Chen SRW, & Welsh DG. (2010) Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves. J Physiol, 588.20:3983-4005.
- Jiang D, Jones PP, Davis DR, Gow R, Green MS, Birnie DH, Chen SR and Gollob MH (2010) Characterization of a Novel Mutation in the Cardiac Ryanodine Receptor that Results in Catecholaminergic Polymorphic Ventricular Tachycardia. Channels. 4(4):.
Commentaries & editorials
- Jones PP and Braun AP (2009) Store operated Ca2+ entry (SOCE): from structure to function. Channels 3(1):1-2.
I am passionately devoted to the study of life, and particularly to the higher forms of life. For me the one great question that has dominated my life is: "What am I?" What is the meaning of this marvelous gift of life? The more we know, the more the mystery grows.