Dr Peter Jones
Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Fax: +64 3 479 7323
Member of Cardiovascular & Respiratory Physiology and Membrane & Ion Transport.
My principal research interest is in how calcium cycling is controlled in cardiac myocytes. In particular my focus is on the mechanisms by which calcium release from intra-cellular stores (sarcoplasmic reticulum, SR) is controlled by the cardiac ryanodine receptor (RyR2). The aim of my research is to characterize how the activity of RyR2 is altered both physiologically and in disease. This is achieved using a broad spectrum of assays from molecular biology and single channel recordings, through to isolated cardiac myocytes and ultimately whole animal models.
Arrhythmia, RyR2, calcium, sarcoplasmic reticulum, RyR1, malignant hyperthermia
- Royal Society of New Zealand Marsden Fund, 2011-2013
- Lottery Health Research, 2011-2012
- Otago Medical Research Foundation, Laurenson Award, 2012-2013 (with Dr Regis Lamberts)
- AIM Fund, Department of Physiology, 2012-2013
- Alberta Heritage Foundation for Medical Research, 2007-2010
- Heart and Stroke Foundation of Alberta, 2008-2010
- Otago Medical Research Foundation, 2010-2011
Badrilla Ltd, www.badrilla.com (characterisation of phosphor-specific cardiac antibodies)
- Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones PP, Tian X, Wilson LS, Ahmad F, Chen SR, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH. (2011) Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca2+ Release and Cardiac Contractility, Independently of L-Type Ca2+ Current. Circ. Res., 109(9):1024-30
- Zhou Q, Xiao J, Jiang J, Wang R, Vembaiyan V, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song L-S, Fill M, Back TG & Chen SRW. (2011) Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat. Med. 17:1003-1009.
- Wang, R., Zhong, X., Meng, X., Koop, A., Tian, X., Jones, P.P., Fruen, B.R., Wagenknecht, T., Liu, Z., & Chen, S.R.W. (2011). Localization of the dantrolene binding sequence near the FKBP binding site in the three-dimensional structure of the ryanodine receptor. Journal of Biological Chemistry, in press.
- Mufti RE, Brett SE, Tran CHT, El-Rahman RA, Anfinogenova Y, El-Yazbi A, Cole WC, Jones PP, Chen SRW, & Welsh DG. (2010) Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves. J Physiol, 588.20:3983-4005.
- Jiang D, Jones PP, Davis DR, Gow R, Green MS, Birnie DH, Chen SR and Gollob MH (2010) Characterization of a Novel Mutation in the Cardiac Ryanodine Receptor that Results in Catecholaminergic Polymorphic Ventricular Tachycardia. Channels. 4(4):.
- Kong H, Jones PP, Koop A, Zhang L, Duff HJ, Chen SR (2008) Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochem. J. 414:441-452.
- Jiang D, Chen W, Xiao J, Wang R, Kong H, Jones PP, Zhang L, Fruen B, Chen SR (2008) Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. J. Biol. Chem. 283(30):20813-20820.
- Jones PP, Jiang D, Bolstad J, Hunt DJ, Zhang L, Demaurex N, Chen SR (2008) Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release. Biochem. J. 412:171-178.
- Jones PP, Meng X, Xiao B, Cai S, Bolstad J, Wagenknecht T, Liu Z, and Chen SR (2007) Localization of PKA Phosphorylation Site, Serine-2030, in the Three-Dimensional Structure of Cardiac Ryanodine Receptor. Biochem. J. 410(2):261-70.
- Xiao J, Tian X, Jones PP, Bolstad J, Kong H, Wang R, Zhang L, Duff HJ, Gillis AM, Kotlikoff M, Copello JA, and Chen SR (2007) Removal of FKBP12.6 Does not Alter the Conductance and Activation of Cardiac Ryanodine Receptor and the Susceptibility to Stress-induced Ventricular Arrhythmias. J. Biol. Chem. 282(48):34828-38.
- Xiao B, Tian X, Xie W, Jones PP, Cai S, Wang X, Jiang D, Kong H, Zhang L, Chen K, Walsh MP, Cheng H, and Chen SR (2007) Functional consequence of PKA-dependent phosphorylation of the cardiac ryanodine receptor: Sensitization of store-overload-induced Ca2+ release (SOICR). J. Biol. Chem. 282(41):30256-64.
- Hunt DJ*, Jones PP*, Wang R, Chen W, Bolstad J, Chen K, Shimoni Y, Chen SR (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem. J. 404(3):431-8. (*Co-first authors)
- Jones PP, Bazzazi H, Kargacin GJ and Colyer J (2006) Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca2+ transient. Biophys. J. 15; 91(2):433-43
Commentaries & editorials
- Jones PP and Braun AP (2009) Store operated Ca2+ entry (SOCE): from structure to function. Channels 3(1):1-2.
The physiology of today is the medicine of tomorrow.