Professor Brian Hyland
Professor/Deputy HoD (Research)
Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Fax: +64 3 479 7323
Member of Cellular & Molecular Neuroscience.
- Neurophysiology of midbrain dopamine systems and pathways which modulate dopamine neuron activity.
- Effects of abnormal dopamine activity such as occurs in Parkinson's disease on activity in the motor control pathways.
Health Research Council, Marsden Fund, Boehringer Ingelheim Pharma GmbH, and New Zealand Neurological Foundation.
- Professor Jeff Wickens, Okinawa Institute of Science & Technology, Japan and Department of Anatomy, Otago
- Professor Gordon Arbuthnott, Okinawa, Japan
- Associate Professor J. Greg Anson, University of Auckland
- Dr Alessandro Villa, Lausanne Switzerland
- Prof. Jason Chen, Tainan, Taiwan
- The most scenic neuroscience conference in the world.
- Otago Basal ganglia Research group
- Sutherland, K.R., Alsop, B., McNaughton, N., Hyland, B.I., Tripp, G., & Wickens, J.R. Sensitivity to delay of reinforcement in two animal models of attention deficit hyperactivity disorder (ADHD) Behavioural Brain Research 205: 372-376, (2009).
- Wu, Y-N., Chen, J-J.J., Zhang, L-Q., & Hyland, B.I. Regulation of hind-limb tone by adenosine A2A receptor in rats. Neuroscience, 159: 1408-1413, (2009).
- Dejean, C., Hyland, B., & Arbuthnott, G. Cortical effects of subthalamic stimulation correlate with behavioral recovery from deopamine antagonist induced akinesia. Cerebral Cortex, 19: 1055-1063, (2009).
- Pan, W-X., Schmidt, R., Wickens, J.R., & Hyland, B.I. Tripartite mechanism of extinction suggested by dopamine neuron activity and temporal difference model. Journal of Neuroscience, 28(39): 9619-9631, (2008).
- Wickens, J.R., Budd, C.S., Hyland, B.I., & Arbuthonott, G.W. Striatal contributions to reward and decision making. Making sense of regional variations in a reiterated processing matrix. Ann NY Acad Sci, 1104: 192-212 (2007).
- Pan, W.X, & Hyland, B.I. Pedunculopontine tegmental nucleus controls conditioned responses of midbrain dopamine neurons in behaving rats. J Neurosci. 25: 4725-4732 (2005).
- Pan, W.X., Schmidt, R., Wickens, J.R., & Hyland, B.I. Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward-learning network. J Neurosci. 25: 6235-6242 (2005).
- Parr-Brownlie, L.C., & Hyland, B.I. Bradykinesia induced by dopamine D2 receptor blockade is associated with reduced motor cortex activity in the rat. J Neurosci. 25: 5700-5709 (2005).
- Reynolds, J.N., Hyland, B.I., & Wickens, J.R. Modulation of an afterhyperpolarization by the substantia nigra induces pauses in the tonic firing of striatal cholinergic interneurons. J Neurosci. 24: 9870-9877 (2004).
- Wickens, J.R., Reynolds, J.N., & Hyland, B.I. Neural mechanisms of reward-related motor learning. Curr Opin Neurobiol 13: 685-90 (2003).
- Hyland, B.I., Reynolds, J.N.J., Hay, J., Perk, C.G., & Miller, R. Firing modes of midbrain dopamine cells in the freely moving rat. Neuroscience 114: 475-492 (2002).
- Reynolds, J.N.J., Hyland B.I., & Wickens J.R. A cellular mechanism of reward-related learning, Nature, 413: 67-70 (2001).
My Summer Research Scholarship in the Department of Physiology was the highlight of my time at the University of Otago as I learnt many new skills, including how to carry out scientific research in a controlled manner, collecting and analyzing scientific data in an orderly fashion, and most importantly, learning to read and think critically.
For more information on the Summer Research Programme, click here