Dr Phil Heyward
Department of Physiology
Otago School of Medical Sciences
University of Otago
PO Box 913
Fax: +64 3 479 7323
Member of Cellular & Molecular Neuroscience.
- The sense of smell: Our ability to sense airborne chemicals is based on patterns of neuronal activity in the brain. We use electrophysiological recording from brain slices maintained in vitro to study how these patterns of activity are processed by individual neurons and circuits in the brain.
- Neurological disorders: Bipolar disorder, depression and epilepsy seem like very different problems, but they each result from abnormal levels of brain neuron activity. To understand these diseases better and develop better treatments we need to know more about how the current treatments work. We therefore focus our studies on how current treatments act on neurons to control their activity as individuals, and as members of brain circuits.
- Royal Society of New Zealand Marsden Fund (2005-2010): Timing and the sense of smell: how does the brain use time to identify an odour?
- Otago Medical Research Foundation (2004) Effects of Lithium on neuronal metabotropic responses to glutamate in mouse brain slices.
Previous lab personnel
- Postdoctoral Fellow: Dr Emma Coddington, now Ass. Prof., Oregon USA.
- Research Assistant: Liam Farley, now globetrotting;
- Research Students: Cristina Shirley, (PhD, 2009) now post-doc; Charlotte Butler Munro, (BBiomedSci(Hons) (2006), now PhD student; Malinda Tantirigama (BSc(Hons), 2008), now PhD student with Dr Ruth Empson.
- Butler-Munro C., Coddington E.J., Shirley C.H., Heyward P.M. (2010) Lithium Modulates Cortical Excitability in vitro. Brain Research (In press)
- Heyward P. M. (2010) A brain slice bath for physiology and compound microscopy, with dual?sided perifusion. J. Microscopy (In press).
- Wachowiak M, McGann JP, Heyward PM, Shao Z, Puche AC, Shipley MT (2005). Inhibition of olfactory receptor neuron input to olfactory bulb glomeruli mediated by suppression of presynaptic calcium influx. J Neurophysiol. 94: 2700 - 2712.
- Heinbockel T, Heyward P, Conquet F, Ennis M (2004). Regulation of main olfactory bulb mitral cell excitability by metabotropic glutamate receptor mGluR1. J Neurophysiol 92(5): 3085-96. [Epub 2004 Jun 22].
- Puche AC, Heyward P, Shipley MT (2004). Transmembrane dye labeling and immunohistochemical staining of electrophysiologically characterized single neurons. J Neurosci Meth 137(2): 235-40.
- Aungst JL, Heyward PM, Puche AC, Karnup SV, Hayar A, Szabo G, Shipley MT (2003). Center-surround inhibition among olfactory glomeruli. Nature 426: 623-6229.
- Heyward PM, Shipley MT (2003). A device for automated control of pipette internal pressure for patch clamp recording. J Neurosci Methods 123: 109-115.
- Hayar A, Heyward PM, Heinbockel T, Shipley MT, Ennis M. (2001). Direct excitation of mitral cells via activation of alpha-1-adrenergic receptors in rat olfactory bulb slices. J Neurophysiol 86(5): 2173-82.
- Heyward PM, Ennis M, Keller A, Shipley MT (2001). Membrane bistability in olfactory bulb mitral cells. J Neurosci 21: 5311-5320.
- "Glutamate Synapses in Olfactory Neural Circuits" Chapter 18 in the edited book ?Amino Acid Receptor Research?, Paley F, Warfield TE, Nova Science Publishers, NY (2008).
The physiology of today is the medicine of tomorrow.