14th March, 2018
Is a man's grey matter the same as a woman's? The documentary features Professor Allan Herbison and Dr Jenny Clarkson and was made with the support of NZ on Air.
9th February, 2018
Dahlia based diabetes drug developed by Physiology researcher ready for human trials
In partnership with Plant and Food Research, researchers will soon begin human trials of a drug made from dahlias.
9th January, 2018
Otago breakthrough in diabetic heart disease
The molecule responsible for heart disease in diabetics has been identified by University of Otago researchers, greatly improving chances of survival.
13th November, 2017
Otago study could mean hope for infertile couples
Crucial new information about how the brain controls fertility has been unlocked by University of Otago researchers, with their findings just published in prestigious journal Proceedings of the National Academy of Sciences of the United States of America.
13th November, 2017
Phenomenal success for Physiology researchers in latest Marsden funding round
Four 3-year project grants were awarded to Department of Physiology researchers in this year’s Marsden Fund - totalling over $3.8M.
19th March, 2018
Matt Hall, 1-yr PhD Presentation, Department of Physiology
28th August, 2017
Congratulations to Dr Bahn who has been awarded a $60K grant for his project “Identification of oxypurinol transporters to decipher drug-drug interactions in gout treatment”.
Gout is a painful inflammation of the joins due to high serum uric acid (SUA) based mostly on an unhealthy Western diet. The gold standard for gout treatment is allopurinol. Once converted into oxypurinol, it inhibits production of uric acid in the liver and lowers SUA. Gout has been associated with many comorbidities including hypertension, which requires adjustment of allopurinol dosage. These drug-drug interactions render gout treatment with allopurinol ineffective exposing the patient to further gout attacks and the risk of life threatening side effects. As drug-drug interactions are based on competition of drugs at transport proteins we hypothesise transporters of the organic anion transporter family (OATs), which are expressed in liver and kidney, are responsible for the observed drug-drug interaction. By investigating these drug-drug interactions in primary human kidney and liver cells, Dr Bahn aims to identify allopurinol/oxypurinol transporters to resolve these drug-drug interactions and improve management of gout treatment.
Physiology is the stepchild of medicine. That is why Cinderella often turns out the queen.